Background/Hypothesis: Curing of matrix tablet as a function of time may sustain the action of dosage form and reduce the usage of polymer concentration which ultimately leads to reduction in product cost. Method: Eudragit RLPO -based matrix tablets, were manufactured to investigate release rate and mechanism of drug release by fitting the dissolution data obtained to various kinetic models viz. Zero order, First order, Higuchi, Hixon-Crowell and Korsmeyer-Peppas. Scanning electron microscopy was used to assess changes in the microstructure of the tablets and mechanism of drug release. IR spectroscopy, XRD, and DSC studies were performed on cured and uncured matrix formulations for assessing the drug compatibility during curing treatment. Results revealed that Korsmeyer-Peppas model was best suited for all formulations indicating drug release by diffusion and erosion. Dissolution study of various compositions with and without curing, justifies that, timed curing reduces usage of polymer concentration and sustains the action of dosage form. It was also apparent that changes in the microstructure of matrix tablets after curing could be related to the alteration in drug release and was ultimately dependent on polymer concentration and the time of curing. IR spectroscopy, XRD, and DSC showed no change in the crystal form of Lornoxicam. Conclusion: With curing, lower concentration of polymer is sufficient to achieve desired drug release from matrix tablet which ultimately leads to reduction in product cost.
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